Super Bowl 2024 odds, spread, line: 49ers vs. Chiefs picks, predictions by San Francisco expert who’s 22-5

The Kansas City Chiefs will try to become the first back-to-back winners in 20 years when they face the San Francisco 49ers on Sunday in Super Bowl 58. Kansas City (14-6) defeated Philadelphia, 38-35, last postseason for its second championship in four years and can be the first team to successfully defend its title since New England accomplished the feat in 2004. San Francisco (14-5) is hoping to avenge its 31-20 loss to the Chiefs in Super Bowl 54 and capture the crown for the sixth time, which would tie the club with Pittsburgh and the Patriots for most Super Bowl victories in NFL history.

Kickoff for Super Bowl LVIII at Allegiant Stadium in Las Vegas is set for 6:30 p.m. ET on CBS and Paramount+. San Francisco is a two-point favorite in the latest 49ers vs. Chiefs odds, per SportsLine consensus, and the over/under for total points scored is 47.5. Before you make any Chiefs vs. 49ers picks or any other Super Bowl 2024 predictions, you need to see what proven SportsLine NFL expert Micah Roberts has to say, considering his mastery of picks involving San Francisco.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. He is 19-12-2 over his last 33 NFL picks, for a profit of $558. Additionally, Roberts is an astounding 22-5 (+1650) on his last 27 against-the-spread picks involving the 49ers. Anyone who has followed him is way up.

Now, Roberts has locked in on 49ers vs. Chiefs in Super Bowl 2024 from every angle and just locked in his picks and predictions. You can visit SportsLine now to see his picks. Here are several Super Bowl 58 odds and betting lines for Chiefs vs. 49ers: 

• 49ers vs. Chiefs spread: San Francisco -2
• 49ers vs. Chiefs over/under: 47.5 points
• 49ers vs. Chiefs money line: San Francisco -127, Kansas City +107
• SF: 49ers are 6-0 straight-up as favorites in the postseason under head coach Kyle Shanahan
• KC: Chiefs QB Patrick Mahomes is 10-1-1 against the spread in his career as an underdog
• 49ers vs. Chiefs: See picks at SportsLine 
• 49ers vs. Chiefs live stream: Paramount+ (try free for seven days)

Why the 49ers can cover

San Francisco’s defense has not performed very well in the playoffs as it has allowed an average of 386 total yards after ranking eighth in the NFL during the regular season (303.9). But it still possesses one of the top pass rushers in the league in Nick Bosa, who was the 2022 Defensive Player of the Year after leading the NFL with 18.5 sacks and registered 10.5 in 2023, giving him 44.5 over the last three seasons – the third-most in that span. The 26-year-old defensive end is the franchise leader with 10 playoff sacks after notching a pair in the 49ers’ 34-31 triumph over Detroit in the NFC Championship Game.

The 49ers have a large assortment of offensive weapons, including 2023 NFL rushing leader Christian McCaffrey. The 27-year-old running back ran for a career-high 1,459 yards and recorded 21 total touchdowns during the regular season to tie former 49er Raheem Mostert for the league lead. McCaffrey ran for a pair of scores in each of the team’s two games this postseason to give him a total of 25 TDs in 2023, the most by a player since LaDainian Tomlinson recorded 33 in 2006. See which team to back here.

Why the Chiefs can cover

Including Super Bowl 54, Kansas City has won three straight meetings with San Francisco and five of the last six. Patrick Mahomes came up with a tremendous performance against the 49ers in Week 7 of the 2022 season, completing 25-of-34 pass attempts for 423 yards and three touchdowns en route to a 44-23 victory. The 28-year-old also had a strong showing versus San Francisco in their Super Bowl meeting as he earned MVP honors after finishing with 286 passing yards while throwing for two TDs and running for another.

Tight end Travis Kelce and wideout Rachee Rice have been Mahomes’ favorite targets this postseason, as each has recorded at least 20 catches and 220 receiving yards. But someone on which to keep an eye in Super Bowl LVIII is Mecole Hardman, who has been a non-factor in the playoffs thus far as he has two receptions for five yards, a pair of carries for minus-five yards and fumbled the ball out of the end zone against Buffalo in the divisional round. However, the 25-year-old, who signed with the New York Jets as a free agent last March after winning two Super Bowls with the Chiefs but returned in a trade in October, ran for a pair of TDs and also hauled in a scoring pass in last season’s triumph over the 49ers. See which team to pick here.

How to make 49ers vs. Chiefs picks

Roberts has analyzed 49ers vs. Chiefs in Super Bowl 58 and while we can tell you he’s leaning Under the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s sharing what it is, and which side to back, only at SportsLine.

Who wins Chiefs vs. 49ers in Super Bowl 2024, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Chiefs vs. 49ers spread hits hard, all from the expert who is an amazing 22-5 on picks involving San Francisco, and find out.