Week 1 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay would return 25-1

Ravens quarterback Lamar Jackson will try to repeat his success on Kickoff Weekend when the Baltimore Ravens take on the New York Jets. The 2019 NFL MVP, Jackson has compiled a 3-0 record as a starter and has nine touchdown passes and no interceptions in four career Week 1 games. His 145.4 passer rating is the highest ever by a quarterback on Kickoff Weekend. Baltimore is favored by 6.5 points in the latest NFL odds from Caesars Sportsbook, but which team should you back with your NFL bets? The game is one of 16 on a loaded Week 1 NFL schedule. Other key NFL matchups include the Cowboys and Buccaneers squaring off in a rematch of the Week 1 classic from last season, and the Broncos’ Russell Wilson returning to Seattle to face his former team, the Seahawks. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine. 

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Indianapolis Colts to cover as eight-point road favorites against the Houston Texans. The Colts are in their fifth season under head coach Frank Reich, who is 37-28 in four seasons in Indianapolis and has led the team to two playoff appearances. The Texans are beginning the Lovie Smith era in Houston. He is 89-87 in his career with the Bears and Buccaneers.

The Colts have a dangerous pass-catching weapon in Michael Pittman Jr. A third-year receiver out of USC, Pittman last season had more receiving yards (1,082) than Mike Evans, more receptions (88) than Ja’Marr Chase and more receiving touchdowns (six) than A.J. Brown. On Sunday, he takes on a Texans defense that allowed 242.2 passing yards per game last season, which ranked 23rd in the NFL. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine. 

What are the model’s top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 138-97 run on its top-rated picks, and find out.