NFL DFS, Week 16: Best DraftKings, FanDuel daily Fantasy football picks, stacks, lineup advice

Scouring the NFL DFS player pool and finding the best matchups and the players with the highest ceilings is a challenge every week. It’s a task made even more complicated by the league’s recent COVID-19 outbreak. The league reduced the amount of time it takes to test off of the COVID-19 list, but there’s still a lot of uncertainty in just about every game. Travis Kelce and Tyreek Hill are both coming off massive games against the Chargers. Both, however, are in jeopardy of missing a Week 16 matchup with the Steelers after positive tests.

Kelce has confirmed that he’s vaccinated, so he’ll be eligible to return if he remains asymptomatic and tests negative twice. But if either he or Hill can’t come back, how should it impact your decision-making? And who else should you be targeting for your Week 16 NFL DFS lineups? Before locking in NFL DFS picks for Week 16, be sure to check out the NFL DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to the Week 16 NFL schedule and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Week 16

One of McClure’s top NFL DFS picks for Week 16 is Jaguars running back James Robinson ($5,900 on DraftKings, $8,200 on FanDuel). After rushing for over 1,000 yards and producing 1,414 scrimmage yards and 10 total touchdowns as a rookie, Robinson looked like he’d see touches reduced in 2021 after the Jaguars drafted Travis Etienne in the first round.

However, Etienne suffered Lisfranc injury and Robinson has continued to excel as a No. 1 back despite playing in an abysmal offense. Robinson is averaging 4.7 yards per carry and has produced 979 scrimmage yards while scoring eight touchdowns in 13 games. He’s produced double-digit Fantasy points on FanDuel and DraftKings in eight of his last 11 games and he’s a solid bet to do so again as the Jaguars take on the Jets in Week 16.

Part of McClure’s optimal NFL DFS strategy includes rostering Rams wide receiver Cooper Kupp ($8,800 on DraftKings and $9,500 on FanDuel). The former third-round pick out of Eastern Washington pretty quickly established himself as a threat in this league despite playing for an FCS school. He had 186 catches for 2,135 yards and 13 touchdowns in his last two seasons.

But Kupp has elevated his game in 2021 and is on track for one of the greatest receiving seasons in the history of the NFL. Entering Week 16, Kupp leads the league in receptions (122), receiving yards (1,625) and receiving touchdowns (14). He’s an excellent route runner, has great body control, catches almost everything thrown his way and he’s dynamic after the catch. He’s had at least 20 points on both sites in nine of 14 games this season and he’s a must-start until someone proves they can stop him.

How to set NFL DFS lineups for Week 16

McClure is also targeting an undervalued player who is set to explode for huge numbers in Week 16. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here. 

So who is Mike McClure putting in his optimal NFL DFS lineups for Week 16? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2 million in winnings, and find out.