NCAA Tournament 2022 odds, lines, Sweet 16 picks, March Madness predictions: Model high on Gonzaga, Miami

The West Region of the 2022 NCAA Tournament bracket is the only quadrant that saw the top-four seeds advance to the March Madness Sweet 16. Gonzaga, the No. 1 overall seed, used a second half surge to beat the Memphis Tigers on Saturday, and now the Zags will square off against the Arkansas Razorbacks. Meanwhile, Mike Krzyzewski secured his 1,200th victory when the Duke Blue Devils beat the Michigan State Spartans. The Blue Devils will meet the Texas Tech Red Raiders in the 2022 NCAA Tournament Sweet 16 on Thursday.

The latest 2022 NCAA Tournament odds from Caesars Sportsbook list the Red Raiders as one-point favorites. The Zags are favored by 8.5 against the Razorbacks, who have won 17 of their last 20 games. Should you back Gonzaga to cover the spread or should you look elsewhere for value in the 2022 March Madness odds? All of the 2022 NCAA Tournament lines for the March Madness Sweet 16 are listed below, and SportsLine’s advanced computer model has all the college basketball betting advice and predictions you need to make the best Sweet 16 picks now.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

The model absolutely crushed its March Madness picks last tournament, beating over 92 percent of all CBS Sports brackets for the second time in three years. The model also nailed a whopping three teams in the Final Four last year. 

Now, it has turned its attention to the latest 2022 NCAA Tournament odds and locked in picks for every Sweet 16 matchup. Head to SportsLine now to see every pick.

Top 2022 NCAA Tournament Sweet 16 predictions

One of the model’s strongest Sweet 16 picks is that Gonzaga (-8.5) covers the spread against Arkansas. The Bulldogs have been the best shooting team in college basketball all season long, which was on full display in Saturday’s victory over Memphis. The Zags scored 51 points in the second half and enter Thursday’s matchup against Arkansas knocking down 52.6 percent of their field-goals this season.

In addition to an elite offense, Gonzaga features a ferocious defense that continues to create havoc. The Bulldogs are securing 32.1 defensive rebounds per game, which ranks first in the country. Gonzaga ranks second in the nation in field-goal percentage allowed (37.9), one of the main reasons why the Zags are covering the spread in well over 70 percent of simulations.

Another one of its 2022 NCAA Tournament predictions: The Miami Hurricanes (-2.5) cover against the Iowa State Cyclones. The Hurricanes put on a show against the No. 2 seed Auburn Tigers on Sunday, securing a 79-61 victory. 

Miami’s Charlie Moore stuffed the stat sheet in the win over the Tigers, recording 15 points, nine rebounds, eight assists and three steals. Moore has now scored at least 15 points in his last four games, keying a Miami offense that is averaging just 9.3 turnovers per game, the sixth-best mark in college basketball. The Hurricanes will have ample opportunities on the offensive end of the floor, as the Cyclones rank 326th in the nation in defensive rebounds per game (22.65). According to SportsLine’s model, Miami is covering the spread 60 percent of the time. 

How to make 2022 NCAA Tournament picks

The model has also made the call on who will win and cover every other Sweet 16 matchup and has identified a No. 1 seed that goes down hard. It also says an underdog wins outright well over 60 percent of the time. You can only get every pick for every game at SportsLine.

So which NCAA Tournament picks can you make with confidence, and which underdog is a must-back? Check out the latest Sweet 16 odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has crushed its college basketball picks, and find out.

NCAA Tournament Sweet 16 odds, spreads, lines

Gonzaga vs. Arkansas (+8.5, 154.5)
Michigan vs. Villanova (-5, 135)
Texas Tech vs. Duke (+1, 136.5)
Houston vs. Arizona (-2, 145)
Saint Peter’s vs. Purdue (-12.5, 135.5)
Providence vs. Kansas (-7.5, 141.5)
North Carolina vs. UCLA (-2, 142)
Iowa State vs. Miami (-2.5, 133)