Chiefs vs. Chargers odds, spread: Thursday Night Football picks, prediction from NFL model on 132-96 roll

The Los Angeles Chargers (8-5) will host the Kansas City Chiefs (9-4) in a primetime battle between AFC West rivals on Thursday Night Football. The Chargers defeated the New York Giants last week to win their second straight game. The Chiefs completely dominated the Las Vegas Raiders last Sunday en route to a 48-9 victory. This was Kansas City’s sixth consecutive win. Kansas City leads the all time series with the Chargers 64-58-1.

Kickoff from SoFi Stadium is set for 8:20 p.m. ET. Kansas City is favored by four points in the latest Chiefs vs. Chargers odds from Caesars Sportsbook, while the Over-Under is 51.5. Before locking in any Chargers vs. Chiefs picks, be sure to check out the NFL predictions and betting advice from the red-hot SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Chiefs vs. Chargers 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Chiefs vs. Chargers:

• Chiefs vs. Chargers spread: Kansas City -4 
• Chiefs vs. Chargers over-under: 51.5 points 
• Chiefs vs. Chargers money line: Kansas City -200, Los Angeles +170 
• KC: Chiefs are 4-0 against the spread in their last four games overall 
• LAC: Chargers are 5-1 ATS in their last six Thursday games

Why the Chiefs can cover

Las Vegas players marched to center field and stood on Kansas City’s logo prior to kickoff in their Week 14 matchup. In response, the Chiefs came out and completely owned the Raiders, blowing them out 48-9. Kansas City outgained Las Vegas 372-290 in the rout.

Patrick Mahomes was stellar against Las Vegas, completing 20-of-24 passes for 258 yards with two touchdowns. Kansas City’s rushing attack also cooked on Sunday afternoon, finishing with 132 rushing yards and three touchdowns. Derrick Gore led Kansas City with 61 rushing yards, including a 51-yard carry for a score. Clyde Edwards-Helaire added another two rushing touchdowns. 

Why the Chargers can cover

Los Angeles has one of the top young signal-callers in the league, second-year pro Justin Herbert. The Oregon product is third in the NFL in passing yards (3,822), tied for second in passing touchdowns (30), and is second in QBR (67.5). The 2020 sixth overall pick has thrown for more than 300 yards in seven games thus far. Herbert just missed that mark in the Week 14 win against the New York Giants but still played sound football.

The 2020 NFL Offensive Rookie of the Year has an absolute rocket for an arm. He unloaded a 59-yard bomb to Jalen Guyton for a score before halftime in that game.

How to make Chiefs vs. Chargers picks 

SportsLine’s model is leaning over on the point total, projecting the teams to combine for 52 points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only see the model’s Chiefs vs. Chargers picks at SportsLine. 

So who wins Chargers vs. Chiefs on Thursday Night Football? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Chargers vs. Chiefs spread to jump on, all from the advanced model that is up almost $7,000 on its NFL picks, and find out.