Cavaliers vs. Pistons odds, line, prediction, start time: 2025 NBA picks, Jan. 27 best bets from proven model

The Cleveland Cavaliers (36-9) will look to continue their dominance over the Detroit Pistons (23-22) when the two meet as part of Monday’s NBA schedule. Cleveland has won 10 straight versus Detroit, going undefeated since Feb. 2022, including a 113-101 home victory on Oct. 25. However, Cleveland has just three against-the-spread (ATS) victories over its last nine games of the 2024-25 NBA season, while Detroit has just three ATS defeats over its last nine games. Detroit is 24-20-1 versus the spread this year, while Cleveland is an Eastern Conference-best 29-16 versus the line.

Tip-off is at 7 p.m. ET from the Rocket Mortgage FieldHouse in Cleveland, where the Cavaliers are an NBA-best 21-3 this season. The Cavs are 11-point favorites in the latest Pistons vs. Cavaliers odds from SportsLine consensus, while the over/under for total points is 235, up from opening at 232.5. Cleveland is at -541 on the money line (risk $541 to win $100), while Detroit is at +398 (risk $100 to win $398). Before you make any Cavaliers vs. Pistons picks, make sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 15 of the 2024-25 NBA season on a sizzling 140-100 roll on all top-rated NBA picks dating back to last season, returning well over $3,000. Anyone following at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Cleveland vs. Detroit 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Cavs vs. Pistons:

• Pistons vs. Cavaliers spread: Cleveland -11
• Pistons vs. Cavaliers over/under: 235 points
• Pistons vs. Cavaliers money line: Cleveland -541, Detroit +398
• Pistons vs. Cavaliers picks: See picks at SportsLine
• Pistons vs. Cavaliers streaming: FuboTV (Try for free)

Why the Cavaliers can cover

Ten straight victories over their divisional rival displays why the Cavaliers can cover versus Detroit, and many of those games were not even close. Cleveland’s average margin of victory over this stretch is 13.4 points, and its average MOV over the last five home matchups is 15.8 points. The Cavs’ 21-3 record at home is the best in the NBA, and the Cavaliers boast the best offense in the NBA in a myriad of categories.

Cleveland ranks first in offensive rating, first in 2-point percentage and first in 3-point percentage. Additionally, it ranks second in points per game, overall field goal percentage and made 3-pointers per game. Meanwhile, Detroit struggles to defend on the perimeter, ranking 22nd in 3-point makes allowed per game and 25th in 3-point percentage allowed. The Pistons also don’t create turnovers on that end of the court as just three teams average fewer steals per game than Detroit, which may be without veteran, Tobias Harris (head), who is listed as questionable. See which team to back at SportsLine.

Why the Pistons can cover

Despite the Cavs’ brilliance this season, they enter on a three-game losing streak, also losing ATS in all three of those contests. Additionally, Detroit is one of the league’s best teams against the spread, both on the road and as an underdog. The Pistons are 15-8-1 ATS in away arenas, which is the third-best mark in the league, and only five teams have a better cover rate than Detroit as an underdog this season.

Detroit has a rising star in Cade Cunningham, who could be the best player on the court any time he laces up his sneakers. He’s coming off a 35-point, 11-assist outing versus Orlando’s No. 2-ranked defense, which followed 29 points and 11 assists in a victory over Atlanta. Cunningham also has help with veteran sharpshooters, Malik Beasley (16.2 points) and Tim Hardaway Jr. (11.1 points), both of whom are shooting at least 38% from downtown. Plus, the Pistons get to face a depleted Cavs team that will be without three rotation players in Caris LeVert (wrist), Dean Wade (knee) and Isaac Okoro (shoulder). See which team to back at SportsLine.

How to make Cavaliers vs. Pistons picks

SportsLine’s model has simulated Pistons vs. Cavaliers and is leaning Under the total, projecting 230 combined points. The model also says one side of the spread hits in almost 60% of simulations. You can head to SportsLine to see the model’s NBA picks. 

So who wins Cavs vs. Pistons on Monday, and which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the Pistons vs. Cavs spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.