Bills vs. Titans odds, spread, line: Monday Night Football picks, predictions from NFL model on 139-98 run

The Tennessee Titans (0-1) will visit the Buffalo Bills (1-0) in the first half of a Monday Night Football doubleheader to round out the Week 2 NFL schedule. This primetime matchup features Buffalo quarterback Josh Allen, receiver Stefon Diggs, and safety Micah Hyde. On the opposite side, Tennessee has running back Derrick Henry, quarterback Ryan Tannehill, and safety Kevin Byard. The Bills are one of the top 2023 Super Bowl favorites, while the Titans were the top seed in the AFC playoff picture last season.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:15 p.m. ET. Buffalo is favored by 10 points in the latest Bills vs. Titans odds from Caesars Sportsbook, and the over/under is 47.5. Before making any Titans vs. Bills picks, you need to see the NFL predictions and betting advice from SportsLine’s advanced computer simulation model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Titans and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Titans vs. Bills:

• Bills vs. Titans spread: Buffalo -10
• Bills vs. Titans over/under: 47.5 points
• Bills vs. Titans money line: Tennessee +360, Buffalo -480
• TEN: Titans are 8-2 ATS in their last 10 Monday games
• BUF: Bills are 3-0-1 ATS in their last four home games
• Bills vs. Titans picks: See picks here

Why the Bills can cover

Buffalo had a dominating and stifling defense in 2021. The Bills were first in the league in total yards allowed (272.8) and passing yards allowed (163). This unit is returning with new additions like edge-rusher Von Miller and rookie cornerback Kamir Elam. In the Week 1 win over Los Angeles, Buffalo held the Rams to 243 yards of total offense.

The pass rush was furious in this contest, logging seven sacks. Miller finished with two sacks and three tackles for loss. Buffalo didn’t blitz once on any of its seven sacks, and the unit also snagged three interceptions. Safety Jordan Poyer is a disciplined and well-rounded defender on the backend. Last week, Poyer finished with two tackles and one interception.

Why the Titans can cover

The Titans’ defense has a range of difference-makers. Safety Kevin Byard shines in different aspects of the game. Byard is a team leader and one of the best at his position in the NFL. The two-time Pro Bowl selection plays with strong anticipation. In the Week One loss, he led the team with 12 total tackles.

Defensive tackle Jeffery Simmons is a clog in the middle of the front four. Simmons plays the position with tremendous tenacity and force. The Mississippi State product is an effective and explosive pass rusher on the inside. He has burst and pursuit when in the backfield. Last week, he logged six total tackles, two sacks, and one forced fumble.

How to make Bills vs. Titans picks

SportsLine’s model is leaning Over on the total, with the teams projected to combine for 51 points. The model also says one side of the spread cashes in well over 50% of simulations. You can only see the model’s MNF picks at SportsLine.

So who wins Titans vs. Bills on Monday Night Football? And which side of the spread cashes well over 50% of the time? Visit SportsLine now to see which side of the Titans vs. Bills spread you need to jump on Monday, all from the model on a 139-98 roll on NFL picks, and find out.