49ers vs. Packers odds, line: 2022 NFL playoff picks, Divisional round prediction by model on 137-97 roll

When the San Francisco 49ers last visited the Green Bay Packers for a playoff game in 2013, the temperature at kickoff was five degrees, the fourth-coldest postseason contest in the history of Lambeau Field. San Francisco managed to post a 23-20 victory in that wild-card game, winning on a 33-yard field goal by Phil Dawson as time expired. The 49ers (11-7) will encounter brutal elements again on Saturday when they visit the NFC North-champion Packers (13-4) for a divisional round matchup in the 2022 NFL playoffs. When San Francisco and Green Bay take the field for their fourth playoff meeting since 2012, the temperature at Lambeau Field is expected to be around two degrees.

Kickoff from Lambeau Field is set for 8:15 p.m. ET. Green Bay is a six-point favorite in the latest 49ers vs. Packers odds from Caesars Sportsbook, while the over-under for total points scored is 47. Before locking in any Packers vs. 49ers picks, make sure check out the latest NFL playoff predictions and betting advice from SportsLine’s proven projection model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters the divisional round of the 2021 NFL playoffs on an incredible 137-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 14 of the regular season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Packers vs. 49ers on Saturday and just locked in its NFL playoff picks and predictions. You can visit SportsLine now to see the model’s picks. Here are the NFL odds and Divisional round betting lines for 49ers vs. Packers:

• 49ers vs. Packers spread: Green Bay -6
• 49ers vs. Packers over-under: 47 points 
• 49ers vs. Packers money line: Green Bay -250, San Francisco +205
• GB: Packers are 11-1 against the spread in their last 12 games following a straight-up loss 
• SF: 49ers are 6-1 ATS in their last seven contests as underdogs

Why the Packers can cover

San Francisco was third in total defense (310 yards) during the regular season and limited Dallas to 307 yards of offense in last Sunday’s wild-card victory, but Rodgers could be facing a depleted unit on Saturday. Nick Bosa, who was fourth in the NFL with a career-high 15.5 sacks, suffered a concussion against the Cowboys in the first half, while fellow defensive end Jordan Willis went down with an ankle injury. Linebacker Fred Warner also sprained his ankle. The early feeling is that the 25-year-old Warner, who led the 49ers with 137 tackles, is the most likely of the three to be in the lineup against Green Bay.

Rodgers could have a field day against the 49ers If Bosa and Willis are unavailable. Green Bay’s aerial attack was eighth in the NFL (253.8 yards) during the regular season and Rodgers threw a league-low four interceptions for the second time in three years.

Why the 49ers can cover

49ers quarterback Jimmy Garoppolo entered the 2022 NFL playoff bracket with a thumb injury and suffered a slightly sprained shoulder in last Sunday’s 23-17 wild-card victory at Dallas. The 30-year-old never has started an NFL game with a kickoff temperature below 40 degrees and has lost the two coldest of his career, a 40-degree start at Baltimore in 2019 and a 41-degree contest at Seattle last month. However, San Francisco already has proven it can defeat Green Bay in the NFL playoffs without an effective Garoppolo, winning 37-20 at home in the 2019 NFC Championship Game behind a ground attack that amassed 285 yards while the quarterback was 6-of-8 passing for 77 yards.

Garoppolo went toe-to-toe with Aaron Rodgers in the 49ers’ 30-28 home loss to Green Bay in Week 3 this season, finishing with four fewer passing yards (257) while matching the reigning NFL MVP with a pair of touchdown tosses. On Saturday, he’ll likely hand the ball off to rookie Elijah Mitchell, who nearly rushed for 1,000 yards (963) in only 11 games in 2021. Deebo Samuel also could be a big part of the running game, as he was second on the 49ers with 365 yards and led the team with eight rushing TDs.

How to make Packers vs. 49ers picks

SportsLine’s model is leaning Under on the point total. In fact, it’s calling for 46 total points. It also says one side of the spread cashes in well over 50 percent of simulations. You can only get the model’s 49ers vs. Packers picks at SportsLine.

So who wins Packers vs. 49ers on Saturday in the NFL playoffs 2022? And which side of the spread cashes well over 50 percent of the time? Visit SportsLine now to see which side of the Packers vs. 49ers spread to be all over, all from the advanced model that is up more than $7,500 on its top-rated NFL picks, and find out.