2022 NFL Playoff odds, picks, line: Bills vs. Patriots prediction, Wild Card bets from expert who’s 20-11

A spot in the divisional round of the 2022 NFL playoffs will be on the line when two AFC East rivals, the Buffalo Bills and New England Patriots, collide in an NFL Super Wild Card Weekend 2022 game on Saturday night. The Bills (11-6) are coming off their second straight divisional title and enter the playoffs as the No. 3 seed in the AFC playoff bracket. The Patriots (10-7) return to the postseason after a one-year absence and are the No. 6 seed. The teams split their two meetings this season, with New England winning in Week 13 in Buffalo and the Bills prevailing in Week 16 in Foxborough. 

Kickoff is set for 8:15 p.m. ET. Buffalo is a four-point favorite in the latest Bills vs. Patriots odds from Caesars Sportsbook, while the Over-Under for total points scored is 44. Before making any Patriots vs. Bills picks or NFL playoff predictions, you need to see the Wild Card picks from legendary handicapper Hammerin’ Hank Goldberg at SportsLine. 

A beloved national treasure, Goldberg enjoyed 15 winning seasons in his 17-year ESPN run. In 2017, Hammer competed against 10 top handicappers in the Las Vegas Review-Journal’s NFL Challenge and beat them all, finishing 50-29-6 in against-the-spread picks. 

He also has a keen eye for both of these teams, especially Buffalo. He 20-11-2 (+763) in his last 33 against-the-spread picks in games involving the Bills and 18-11 (+571) in his last 29 against-the-spread picks in games involving the Patriots. Anyone who has followed him is way up.

Now, he has locked in on the Bills vs. Patriots Wild Card game and released a confident against-the-spread pick. You can head to SportsLine now to see Goldberg’s Wild Card Weekend picks. Now, here are the NFL odds and Wild Card betting lines for Patriots vs. Bills on Saturday:

• Bills vs. Patriots spread: Buffalo -4 
• Bills vs. Patriots Over-Under: 44 points 
• Bills vs. Patriots money line: Buffalo -210, New England +175 
• BUF: Bills led the league in total defense (272.8 total yards per game) 
• NE: Patriots were No. 2 in the NFL in scoring defense (17.8 points per game)

Why the Bills can cover

Josh Allen has established himself as one of the league’s top quarterbacks. The No. 7 overall pick in the 2018 NFL Draft, Allen had 42 combined passing and rushing touchdowns during the regular season; only Tom Brady (45) had more. Allen also joined Brady, Patrick Mahomes and Aaron Rodgers as the only quarterbacks to have 4,000 passing yards and 35 passing touchdowns in each of the past two seasons.

In addition, running back Devin Singletary finished the season on a roll. The third-year running back from Florida Atlantic had just seven rushing touchdowns this season, but five came over the last four games. He also has rushed for 80-plus yards in three of his last four games.

Why the Patriots can cover

Damien Harris has had success against the Bills in his career. The third-year running back from Alabama has rushed for 100 yards and scored a touchdown in each of his three games against Buffalo. The last time he faced the Bills, Harris rushed for three touchdowns, tied for the most by a Patriots player in a game against Buffalo in franchise history.

In addition, J.C. Jackson has been a shutdown corner. Only the Cowboys‘ Trevon Diggs (11) had more interceptions this season than Jackson (eight). Jackson has 25 interceptions in his first four seasons, tied for the most by a player since the NFL merger. 

How to make Bills vs. Patriots picks

Hammer, who has inside sources throughout the league, has analyzed this matchup and while we can tell you he’s leaning Under on the point total, he has discovered a crucial x-factor that makes one side of the spread a must-back. He’s sharing what it is, and which side of the Patriots vs. Bills spread to back only at SportsLine.

Who wins Patriots vs. Bills in the NFL playoffs 2022? And what critical factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Bills vs. Patriots spread you should jump on, all from the NFL handicapping legend who is 20-11 on picks in games involving the Bills, and find out.